021-51111890
购物车（0）
sales@molnova.cn
CP 316311
CAS No. 175139-41-0
CP 316311 ( —— )
产品货号. M33325 CAS No. 175139-41-0
CP 316311 是一种有效的，选择性的 CRF1 receptor 拮抗剂，IC50 值为 6.8 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥3786 | 有现货 |
|
| 5MG | ￥4304 | 有现货 |
|
| 10MG | ￥5515 | 有现货 |
|
| 25MG | ￥7257 | 有现货 |
|
| 50MG | ￥9853 | 有现货 |
|
| 100MG | ￥12852 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称CP 316311
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述CP 316311 是一种有效的，选择性的 CRF1 receptor 拮抗剂，IC50 值为 6.8 nM。
-
产品描述CP 316311 is a potent and selective CRF1 receptor antagonist with an IC50 value of 6.8 nM.
-
体外实验CP 316311 fully antagonizes CRF-stimulated adenylate cyclase activity in rat cortex and at human CRF1 receptors endogenously expressed in IMR32 cells with apparent Ki values of 7.6 and 8.5 nM, respectively.
-
体内实验CP 316311 (3.2 mg/kg) inhibits 125I-oCRF binding by >80% in rats. CP 316311 significantly attenuates activation of the hypothalamic?pituitary?adrenal (HPA) axis, with an MED value of 10 mg/kg, p.o. CP 316311 blocks the effects of both the exogenous and endogenous CRF in the CNS. CP 316311 blocks the effects induced by the exogeneous or endogeneous CRF in the brain in rat models.
-
同义词——
-
通路GPCR/G Protein
-
靶点CRF Receptor
-
受体CRFR
-
研究领域——
-
适应症——
化学信息
-
CAS Number175139-41-0
-
分子量327.46
-
分子式C21H29NO2
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESN=1C(OC=2C(=CC(=CC2C)C)C)=C(C(OC(CC)CC)=CC1C)C
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Chen YL, et al. Synthesis and SAR of 2-aryloxy-4-alkoxy-pyridines as potent orally active corticotropin-releasing factor 1 receptor antagonists. J Med Chem. 2008 Mar 13;51(5):1377-84.?
产品手册
关联产品
-
K 41498
Potent and highly selective CRF2 receptor antagonist (Ki values are 0.66, 0.62 and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. In rats in vivo, blocks urocortin-induced hypotension following systemic administration.
-
CRF, bovine
CRF, bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM.
-
Pexacerfont
一种有效的、选择性的、口服活性的 CRF1 受体拮抗剂，IC50 为 6.1 nM，选择性是 CRF 结合蛋白和生物胺受体的 1,000 倍以上。
